Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel
The
formulation of a potential delivery system based on liposomes (Lips) formulated
from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips).
At
first, PTX-Lips were prepared by thin film method using SL and cholesterol and
then were characterized for their physiochemical properties (particle size,
polydispersity index, zeta potential, and morphology).
The
results indicated that PTX-Lips were spherical in shape with a dynamic light
scattering (DLS) particle size of 131 +/- 30.5 nm.
Besides,
PTX was efficiently encapsulated in Lips, 94.5 +/- 3.2% for drug loading
efficiency, and slowly released up to 96 h, compared with free PTX.
More
importantly, cell proliferation kit I (MTT) assay data showed that Lips were
biocompatible nanocarriers, and in addition the incorporation of PTX into Lips
has been proven successful in reducing the toxicity of PTX.
As
a result, development of Lips using SL may offer a stable delivery system and
promising properties for loading and sustained release of PTX in cancer
therapy.
| Title: | Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel |
| Authors: | Nguyen Thi Lan Nguyen Thi Hiep Nguyen Dai Hai |
| Keywords: | RESISTANT LUNG-CANCER DRUG-DELIVERY NANOPARTICLES DOXORUBICIN EFFICACY THERAPY RELEASE GROWTH PEG |
| Issue Date: | 2017 |
| Publisher: | HINDAWI LTD, ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND |
| Citation: | ISIKNOWLEDGE |
| Abstract: | The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 +/- 30.5 nm. Besides, PTX was efficiently encapsulated in Lips, 94.5 +/- 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy. |
| Description: | TNS07016 ; INTERNATIONAL JOURNAL OF BIOMATERIALS Article Number: 8234712 Published: 2017 |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/28833 |
| ISSN: | 1687-8787 1687-8795 |
| Appears in Collections: | Bài báo của ĐHQGHN trong Web of Science |
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